Decreased adrenal medullary catecholamines in adrenal transplanted parkinsonian patients compared to nephrectomy patients
Identifieur interne : 002807 ( Main/Exploration ); précédent : 002806; suivant : 002808Decreased adrenal medullary catecholamines in adrenal transplanted parkinsonian patients compared to nephrectomy patients
Auteurs : Susan L. Stoddard [États-Unis] ; J. Eric Ahlskog [États-Unis] ; Patrick J. Kelly [États-Unis] ; Gertrude M. Tyce [États-Unis] ; Jon A. Van Heerden [États-Unis] ; Alan R. Zinsmeister [États-Unis] ; Stephen W. Carmichael [États-Unis]Source :
- Experimental Neurology [ 0014-4886 ] ; 1989.
Abstract
Adrenal medullary catecholamines were measured in tissue samples from eight patients who underwent autologous transplantation of the adrenal medulla to the caudate nucleus as a treatment for Parkinson's disease. These adrenal catecholamine levels were compared to a group of patients of similar age who underwent unilateral nephrectomy for renal cell carcinoma. The levels of each catecholamine, expressed as nanomoles per milligram wet weight tissue, were significantly lower (P ≤ 0.005) in the parkinsonian patients than in the nephrectomy patients. These observations support data reported previously from autopsy specimens and suggest that the adrenal medullae of parkinsonian patients may be a compromised source of dopamine-producing tissue; this may limit its effectiveness in eliciting maximum clinical improvement following transplantation.
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DOI: 10.1016/0014-4886(89)90032-0
Affiliations:
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These adrenal catecholamine levels were compared to a group of patients of similar age who underwent unilateral nephrectomy for renal cell carcinoma. The levels of each catecholamine, expressed as nanomoles per milligram wet weight tissue, were significantly lower (P ≤ 0.005) in the parkinsonian patients than in the nephrectomy patients. These observations support data reported previously from autopsy specimens and suggest that the adrenal medullae of parkinsonian patients may be a compromised source of dopamine-producing tissue; this may limit its effectiveness in eliciting maximum clinical improvement following transplantation.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Indiana</li><li>Minnesota</li></region></list><tree><country name="États-Unis"><region name="Indiana"><name sortKey="Stoddard, Susan L" sort="Stoddard, Susan L" uniqKey="Stoddard S" first="Susan L." last="Stoddard">Susan L. Stoddard</name></region><name sortKey="Ahlskog, J Eric" sort="Ahlskog, J Eric" uniqKey="Ahlskog J" first="J. Eric" last="Ahlskog">J. Eric Ahlskog</name><name sortKey="Carmichael, Stephen W" sort="Carmichael, Stephen W" uniqKey="Carmichael S" first="Stephen W." last="Carmichael">Stephen W. Carmichael</name><name sortKey="Kelly, Patrick J" sort="Kelly, Patrick J" uniqKey="Kelly P" first="Patrick J." last="Kelly">Patrick J. Kelly</name><name sortKey="Tyce, Gertrude M" sort="Tyce, Gertrude M" uniqKey="Tyce G" first="Gertrude M." last="Tyce">Gertrude M. Tyce</name><name sortKey="Van Heerden, Jon A" sort="Van Heerden, Jon A" uniqKey="Van Heerden J" first="Jon A." last="Van Heerden">Jon A. Van Heerden</name><name sortKey="Zinsmeister, Alan R" sort="Zinsmeister, Alan R" uniqKey="Zinsmeister A" first="Alan R." last="Zinsmeister">Alan R. Zinsmeister</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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